It is important to follow your Veterinarian's prescription instructions for your pet.
In dogs, the usual dosage is 2.5 to 5 mg per pound 5 to 10 mg/kg orally once daily for up to 7 days
In cats, the usual dosage is 2.5 to 7.5 mg per pound 5 to 15 mg/kg orally every 12 to 24 hours for up to 7 days
The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects.
Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse.
Dosing Informaton for Liquid:
Mixing Directions:
Tap Bottle to loosen powder. Add listed amount of water to the bottle. After mixing, use within 10 days. Discard after full dosing is completed. After mixing, store suspension at 41 to 86 degrees F. Oversized bottle provides extra space for shaking.
Shake Well Before Using.
Administration of Liquid:
For liquids, shake well before accurately measuring the dose. If using the suspension, give on empty stomach. Give medication as directed by your veterinarian. This medication is usually given once or twice daily. Read and follow the label carefully. Give the exact amount prescribed and only as often as directed. Missed doses reduce the effectiveness of therapy. Give this medication for as long as your veterinarian directs. Finish the entire course of treatment. Ideally, give the medication at the same time daily.
Precautions and Side Effects:
Azithromycin should not be used in animals with known hypersensitivity or allergy to it or other macrolide antibiotics. In addition, it should be used with great caution if at all when there is preexisting liver disease. Gastrointestinal side effects may include vomiting, diarrhea, or abdominal pain. Angioedema and cholestatic jaundice have been reported rarely in treated humans. Cardiac arrhythmias, including ventricular tachycardia, may be precipitated by azithromycin. Renal dysfunction, including interstitial nephritis and acute renal failure, may occur secondary to azithromycin treatment and liver function may be affected.
Drug Interactions:
Azithromycin may elevate serum digoxin levels. When ergotamine or dihydroergotamine are concurrently administered with azithromycin ergot toxicity may occur. Azithromycin causes a decrease in the clearance of triazolam and thus an increase in its pharmacologic effects Pimozide is contraindicated in patients receiving azithromycin, and vice versa death may result Animals being treated with cisapride should not be given azithromycin or other macrolide antibiotic Drugs metabolized by cytochrome P450 e.g. carbamazepine, terfenadine, cyclosporine, hexobarbital, and phenytoin will have their serum levels elevated by azithromycin Oral antacids reduce the absorption of azithromycin.
Indications and Usage
Azithromycin for injection is indicated for the treatment of patients with infections caused by susceptible strains of the designated microorganisms in the conditions listed below. As recommended dosages, durations of therapy, and applicable patient populations vary among these infections, please see Dosage and administration for dosing recommendations.
Community-acquired pneumonia due to Chlamydia pneumoniae, Haemophilus influenzae, Legionella pneumophila, Moraxella catarrhalis, Mycoplasma pneumoniae, Staphylococcus areus, or Streptococcus pneumoniae in patients who require initial intravenous therapy.
Pelvic inflammatory disease due to Chlamydia trachomatis, Neisseria gonorrhoeae, or Mycoplasma hominisin patients who require initial intravenous therapy. If anaerobic microorganisms are suspected of contributing to the infection, an antimicrobial agent with anaerobic activity should be administered in combination with azithromyzin for injection.
Azithromycin for injection should be followed by azithromycin by the oral route as required. (See Dosage and Administration.)
Appropriate culture and susceptibility tests should be performed before treatment to determine the causative microorganism and its susceptibility to azithromycin. Therapy with azithromycin may be initiated before results of these tests are known; once the results become available, antimicrobial therapy should be adjusted accordingly.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of azithromycin and other antibacterial drugs, azithromycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Contraindications
Azithromycin is contraindicated in patients with known hypersensitivity to azithromyzin, erythromycin, any macrolide or ketolide antibiotic. |