Sulfamethoxazole and Trimethoprim (SMZ-TMP) Tablets are a combination antibiotic used to treat respiratory, urinary tract, skin, or gastrointestinal infections, and other conditions.
Sulfamethoxazole and Trimethoprim (SMZ-TMP) Tablets are a combination antibiotic used to treat respiratory, urinary tract, skin, or gastrointestinal infections, and other conditions.
Sulfamethoxazole is a sulfonamide antibiotic that limits the growth of bacteria. Sulfonamides inhibit synthesis of folic acid, important to bacterial DNA synthesis. Trimethoprim works by starving the bacteria of nucleotides necessary for DNA replication.
Trimethoprim is a potential sulfa drug with antibacterial properties, which is used in the treatment of many bacterial infections in dogs and cats. It is commonly used against the infections of the lungs, urinary tract, skin and gastrointestinal organs. Trimethoprim is found to be of use in treating conditions like Pneumonia, Enteritis, Otitis media, Prostatitis, Coccidiosis, Kennel cough, and Staphylococcal skin infections among others. The mechanism of Trimethoprim is to hinder the production of tetrahydrofolic acid from dihydrofolic acid by binding to it. Concurrently it also prevents the bacterial production of dihydrofolic acid, thereby offering a dual advantage.
| Directions | Dogs: 15-45 milligrams per kilogram by mouth every 12 hours. Cats: 15-30 milligrams per kilogram by mouth every 12 hours. The medication dosages listed represent the variation in dosing for all underlying medical conditions. |
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