NeoVac DA2 at a glance
| Product | NeoVac® DA2 Canine Distemper-Adenovirus Type 2 Vaccine, Modified Live Virus |
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| Manufacturer | NeoTech, LLC, Dresden, Tennessee (U.S. Veterinary License No. 472, product code 13A1.20) |
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| Label use | Aid in the prevention of disease due to canine distemper virus and canine adenovirus type 1 (infectious canine hepatitis virus) |
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| Vaccine antigens | Canine distemper virus and canine adenovirus type 2 |
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| Does not cover | Parvovirus. Pair it with NeoPar. |
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| Species | Dogs |
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| Dose | 1 mL, rehydrated with the diluent supplied |
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| Route | Subcutaneous (SC) injection |
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| First dose | Dogs at least 42 days of age |
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| Puppy series | Revaccinate every 14 to 28 days until 16 weeks of age |
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| Dogs over 16 weeks | A single 1 mL dose |
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| Booster | Revaccinate annually with one dose |
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| Storage | 2° to 7°C (35° to 45°F) |
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| Preservative | Gentamicin |
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| Pack options | Single-dose kit with syringe; 3, 10 or 25 single doses; one 10-dose vial; five 10-dose vials |
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What NeoVac DA2 is
NeoVac DA2 is a two-way modified live vaccine for dogs, made by NeoTech, LLC in Dresden, Tennessee. The USDA lists it under the true name “Canine Distemper-Adenovirus Type 2 Vaccine, Modified Live Virus.” It contains canine distemper virus and canine adenovirus type 2. The label indication is an aid in the prevention of disease caused by canine distemper virus and by canine adenovirus type 1, the virus behind infectious canine hepatitis.
It does not contain parvovirus, parainfluenza or leptospirosis. That is on purpose. NeoTech built its puppy program around two simple vaccines: NeoVac DA2 for distemper and adenovirus, and NeoPar for parvovirus. Breeders and kennels that use both can schedule each disease separately instead of tying everything to one 5-way shot.
What NeoTech says about NeoVac DA2
NeoTech states the following on its official NeoVac DA2 product page:
- High antigen mass. NeoTech says the vaccine has a high antigen mass, which it links to a short time from vaccination to protection, a higher level of protection and a long duration of immunity.
- Works with maternal antibody present. According to NeoTech, NeoVac DA2 stimulates antibody production in the presence of maternal antibodies.
- Response after the first dose. NeoTech states that antibody production begins after the first dose, and that other DA2 vaccines require 2 or 3 doses to start an initial antibody response.
- No distemper shedding. NeoTech reports no post-vaccination shedding of canine distemper virus.
- Simple combination. NeoTech says a two-antigen vaccine is less likely to cause a vaccine reaction than complex combination vaccines.
Those are the manufacturer's statements. The label directions below are what we follow and what you should follow.
NeoTech's weekly-vaccination kennel study
Commercial kennels that place puppies at 8 weeks often can't keep a 2 to 3 week gap between every vaccine. Some people worry that vaccinating that often leaves a puppy unprotected. NeoTech tested its own weekly program in 20 commercial-kennel puppies. The puppies alternated NeoPar and NeoVac DA2 one week apart, alongside a routine intestinal parasite control program and a kennel cough vaccine at 28 days of age.
| Puppy age | Vaccine in the study |
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| 35 days | NeoPar (parvovirus) |
| 42 days | NeoVac DA2 (distemper-adenovirus) |
| 49 days | NeoPar |
| 56 days | NeoVac DA2 |
Blood was drawn at about 8½ weeks of age and tested for canine parvovirus antibody by serum neutralization. A parvovirus titer of 80 is recognized in the scientific literature as protective against viral challenge. All 20 puppies were above that level, with titers from 100 to more than 5.6 million, and 8 of the 20 had titers of 100,000 or more. NeoTech concluded that its weekly schedule alternating NeoPar and NeoVac DA2 induces a robust level of protection in 8-week-old puppies.
What this study does and does not show for NeoVac DA2: it measured parvovirus antibody only. No distemper or adenovirus titers were reported. So it shows that puppies receiving NeoVac DA2 in the weeks between their NeoPar doses still developed parvovirus titers above the protective level. It does not, by itself, measure distemper or adenovirus protection. Note too that the study's first NeoPar dose at 35 days is earlier than the NeoPar label, which calls for the first dose at or about 42 days. The NeoVac DA2 doses at 42 and 56 days fit its label: first dose at 42 days or older, repeated every 14 to 28 days. Talk with your veterinarian about the schedule that fits your kennel.
Source: NeoTech, LLC internal serological study (September 2023), as provided by the manufacturer.
Who NeoVac DA2 is for, and who should not get it
NeoVac DA2 is labeled for dogs, starting with puppies at least 42 days (6 weeks) old, and for dogs over 16 weeks that need a single dose. Typical buyers are breeders vaccinating litters, kennels keeping adult dogs current, and shelters and rescues vaccinating new intakes.
Per the label, do not vaccinate:
- Pregnant bitches
- Lactating (nursing) bitches
- Sick dogs
- Debilitated dogs
The label also notes that transient corneal opacity (a temporary cloudy eye) may occasionally occur after vaccination. NeoVac DA2 is a canine vaccine. For ferrets, NeoTech makes a separate distemper vaccine, NeoVac FD. For a distemper-only canine vaccine, see NeoVac D.
How to give NeoVac DA2 (label directions)
- Aseptically rehydrate the vaccine with the diluent supplied. Shake well during rehydration.
- Inject 1 dose (1 mL) subcutaneously.
- Give the first dose to dogs at least 42 days of age.
- Maternal antibody can interfere with the immune response to the first vaccination, so revaccinate every 14 to 28 days until the dog is 16 weeks of age.
- Dogs over 16 weeks of age should receive a single 1 mL dose.
- Revaccinate annually with one dose.
Rehydrate only what you plan to use. The label says to burn the container and all unused contents. If you vaccinate a few dogs at a time, single-dose vials avoid waste.
Your veterinarian can help you build a vaccination program that fits your animals. If anything on this page differs from the label on the product you receive, follow the label.
Storage and handling
- Store between 2° and 7°C (35° and 45°F), which is standard refrigerator temperature.
- Shake well during rehydration.
- Gentamicin is used as a preservative.
- Burn the container and all unused contents.
- For animal use only.
Pack sizes
| Option | What you get | Best for |
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| Single dose | Convenience pack: 1 vaccine vial, 1 diluent vial and 1 syringe with needle | One dog, or a top-up |
| 3 × 1 dose | 3 single-dose vaccine vials with diluent | A few dogs or a small litter |
| 10 × 1 dose | 10 single-dose vaccine vials with diluent | Litters and small kennels |
| 25 × 1 dose | 25 single-dose vaccine vials and 25 diluent vials | Kennels that vaccinate a few dogs at a time |
| 10-dose vial | 1 ten-dose vaccine vial and 10 mL of diluent | Vaccinating 10 dogs in one session |
| 5 × 10 dose | 5 ten-dose vaccine vials with diluent, 50 doses total | Large kennels and shelters |
Pick the format that matches how many dogs you vaccinate at one time. Current prices for every option are shown above. Apart from the single-dose convenience pack, you will need a needle and syringe for each dog. See our syringe and needle combos.
How we ship vaccines
From our shipping policy:
- We ship vaccines and perishable items Monday through Wednesday. Orders received by 1 pm EST go out the same day.
- Vaccines ship UPS 2nd Day Air, packed in a styrofoam vaccine shipping cooler with 3 ice packs. The cooler and 3 ice packs are included at no extra charge. Extra ice packs beyond 3 can be added for a fee.
- The ice packs will often have melted by the time the box arrives. That means the packaging did its job. The cooler and ice packs protect the vaccine from big temperature swings in transit; they are not meant to deliver it at refrigerator temperature. Put the vaccine in the refrigerator as soon as it arrives.
- Overnight shipping is available on request: note it at checkout or call 800-979-2869.
- We ship vaccines only within the United States.
- Vaccines and other perishable items cannot be returned or refunded.
Frequently asked questions
What does NeoVac DA2 protect against?
The label indication is an aid in the prevention of disease due to canine distemper virus and canine adenovirus type 1 (infectious canine hepatitis virus). The vaccine contains canine distemper virus and canine adenovirus type 2.
Does NeoVac DA2 include parvovirus?
No. NeoVac DA2 covers distemper and adenovirus only. NeoTech makes parvovirus protection as a separate single-antigen vaccine, NeoPar.
How old does a puppy have to be for NeoVac DA2?
The label says to vaccinate dogs that are at least 42 days (about 6 weeks) of age.
How many doses does a puppy need?
After the first dose, the label says to revaccinate every 14 to 28 days until the puppy is 16 weeks old, then once a year. Maternal antibody can interfere with the response to the first dose, which is why the series is repeated.
What about an adult dog with an unknown vaccine history?
The label says dogs over 16 weeks of age should receive a single 1 mL dose, then be revaccinated annually with one dose.
Is NeoVac DA2 given under the skin or in the muscle?
Under the skin. The label directions are to inject 1 mL subcutaneously.
How do I mix NeoVac DA2?
Aseptically rehydrate the vaccine with the diluent supplied and shake well during rehydration. Each dose is 1 mL. Rehydrate only what you will use; the label says to burn the container and all unused contents.
Can I alternate NeoVac DA2 and NeoPar weekly?
In a NeoTech study, 20 commercial-kennel puppies alternated NeoPar at 35 and 49 days with NeoVac DA2 at 42 and 56 days. At about 8½ weeks, all 20 had parvovirus titers above the protective level of 80. The study measured parvovirus antibody only. Talk with your veterinarian about the schedule that fits your kennel.
Did NeoTech's study measure distemper titers?
No. The weekly-vaccination study reported canine parvovirus serum-neutralization titers only. It did not report distemper or adenovirus titers.
Can I give NeoVac DA2 to a pregnant or nursing dog?
No. The label says not to vaccinate pregnant or lactating bitches, sick dogs or debilitated dogs.
What side effects are listed on the label?
The label says transient corneal opacity may occasionally occur after vaccination. In case of anaphylaxis, epinephrine, corticosteroids and antihistamines may be indicated depending on the nature and severity of the reaction. Contact your veterinarian right away if you see signs of a reaction.
Can I use NeoVac DA2 in ferrets?
NeoVac DA2 is a canine vaccine. For ferrets, NeoTech makes NeoVac FD. Ask your veterinarian which vaccine is right for your animal.
How should NeoVac DA2 be stored?
In the refrigerator, between 2° and 7°C (35° and 45°F).
How do you ship vaccines?
Vaccines ship UPS 2nd Day Air, packed in a styrofoam vaccine shipping cooler with 3 ice packs. The cooler and 3 ice packs are included at no extra charge. Extra ice packs beyond 3 can be added for a fee. Vaccine shipping is a flat rate by zone:
| Zone 1: $29.99 | KS, WI, OK, IL, LA, MI, AR, IN, MO, KY, IA, TN, MS, AL, GA, FL, SC, NC, VA, WV, PA, OH |
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| Zone 2: $39.99 | CT, MA, NJ, NY, RI, TX, VT, DE, MD |
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| Zone 3: $69.99 | CO, NM, NE, SD, ND, MN, CA, UT, NV, WY, AZ, MT, ID, WA, OR, ME, NH |
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| Other states (including AK and HI) | Call 800-979-2869 for a rate |
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Overnight shipping is available for an additional charge: note it in the order comments at checkout or call 800-979-2869.
The ice packs were melted when my order arrived. Is the vaccine OK?
Melted ice packs are expected. The packaging protects the vaccine from large temperature swings during the 2-day trip; it is not designed to arrive at refrigerator temperature. Refrigerate the vaccine as soon as it arrives. Overnight shipping is available on request: note it at checkout or call 800-979-2869.
Can I return vaccines?
No. Vaccines and other perishable items cannot be returned or refunded.
Who makes NeoVac DA2?
NeoTech, LLC of Dresden, Tennessee, under U.S. Veterinary License No. 472. The USDA lists it as product code 13A120, “Canine Distemper-Adenovirus Type 2 Vaccine, Modified Live Virus,” for canine use.
Why buy NeoVac DA2 from A to Z Vet Supply
- Close to the source. We are at 9876 Hwy. 22 in Dresden, Tennessee, on the same highway as NeoTech's facility.
- Every NeoTech pack size on one page. From a single-dose kit with syringe up to five 10-dose vials.
- Both halves of the NeoTech program. We carry NeoVac DA2 and NeoPar, so you can order distemper-adenovirus and parvo vaccines in one place.
- Real people on the phone. Call 800-979-2869, Monday through Friday, 8 am to 5 pm Central.
- Cooler and 3 ice packs included at no extra charge on every vaccine order, shipped UPS 2nd Day Air as described above.
Label information
From the NeoVac DA2 carton label:
Canine Distemper Adenovirus Type 2 Vaccine, Modified Live Virus. NeoVac® DA2. U.S. Veterinary License No. 472. Product Code: 13A1.20. NeoTech, LLC, Dresden, TN 38225 USA.
Directions: For use as an aid in the prevention of disease due to Canine Distemper Virus and Canine Adenovirus Type 1 (infectious canine hepatitis virus). Aseptically rehydrate vaccine with diluent supplied. Inject 1 dose (1 mL) subcutaneously into dogs that are at least 42 days of age. Because there is potential for maternal antibody to interfere with the immune response to the original vaccination, revaccinate every 14 to 28 days until the dog is 16 weeks of age. Dogs over 16 weeks of age should receive a single dose (1 mL). Revaccinate annually with one dose.
Precautions: Store at 2-7°C (35-45°F). Shake well during rehydration. Do not vaccinate pregnant or lactating bitches, sick, or debilitated dogs. Occasionally, transient corneal opacity may occur following the administration of this product. In case of anaphylaxis; epinephrine, corticosteroids, and antihistamines may all be indicated depending on the nature and severity of the reaction. Gentamicin used as a preservative. Burn this container and all unused contents. For animal use only.
This page summarizes the manufacturer's label and published product information. Always read and follow the label on the product you receive, and consult your veterinarian about the right vaccination program for your animals.
