Merck's Nobivac Canine 1-DAPPv is a 5-way modified live vaccine for healthy dogs 6 weeks and older, labeled against canine distemper, adenovirus type 1 (hepatitis) and type 2, parainfluenza and parvovirus. 1 mL SC or IM; two doses 2–4 weeks apart for primary immunization. 25 × 1 mL doses, shipped cold.
Shipping : Perishable
| Product | Nobivac® Canine 1-DAPPv: Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus |
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| Manufacturer | Intervet Inc. d/b/a Merck Animal Health (VLN 165A / PCN 13D1.20) |
| Protects against | Canine distemper virus, canine adenovirus type 1 (hepatitis), canine adenovirus type 2 (respiratory disease), canine parainfluenza virus, canine parvovirus |
| Species / age | Healthy dogs 6 weeks of age or older |
| Dose | 1 mL after reconstitution with the sterile diluent |
| Route | Subcutaneous (SC) or intramuscular (IM) |
| Primary series | First dose at 6 weeks or older, repeat 2 to 4 weeks later. Two doses are required for primary immunization. |
| Storage | 2°–8°C (35°–46°F). Do not freeze. |
| Preservative | Gentamicin. Thimerosal free. |
| Presentation | 25 × 1 mL dose tray |
Nobivac Canine 1-DAPPv is Merck Animal Health's 5-way modified live vaccine for dogs. Merck calls it “a proven foundation for vaccine protocols.” One 1 mL injection covers the five core viral diseases in the name:
It comes as a 25-dose tray. Each dose is a vial of vaccine that you reconstitute with a vial of sterile diluent just before use. That makes it a practical choice for breeders vaccinating litters, kennels keeping adult dogs current, and shelters vaccinating on intake.
Per the Merck label, Nobivac Canine 1-DAPPv “has been shown to be effective for vaccination of healthy dogs 6 weeks of age or older against canine distemper virus, canine adenovirus type 1 (hepatitis), canine adenovirus type 2 (respiratory disease), canine parainfluenza virus and canine parvovirus.” The label also states that duration of immunity has not been established. Efficacy and safety data are published by the USDA at productdata.aphis.usda.gov.
Merck Animal Health also states the following on its product page:
The label also states that data indicate the development of corneal opacity is not associated with the use of this product.
Nobivac Canine 1-DAPPv is labeled for healthy dogs 6 weeks of age or older. Per the label warnings:
Puppies and maternal antibody. The label notes that maternal antibodies are known to interfere with the development of active immunity in dogs, and that additional boosters will be required in most young animals. The age at which maternal antibody for canine parvovirus stops interfering varies with the dam's titer and how much colostral antibody the puppy absorbed.
Boosters. In Merck's words: “Historically, annual revaccination has been recommended for this product. The need for this booster has not been established. For more information on revaccination frequency, in general or in the face of maternal antibody, consult your veterinarian or the manufacturer.”
If anything on this page differs from the label on the product you receive, follow the label.
One 25 × 1 mL dose tray: vials of Nobivac Canine 1-DAPPv vaccine, with the sterile diluent vials used to reconstitute them, one 1 mL dose each.
Merck also makes this vaccine in other formulations. Choose a different one if your dogs need leptospirosis or coronavirus coverage in the same shot:
Browse all 5-way dog vaccines.
From our shipping policy:
D is distemper, A is adenovirus (type 2, with label indications for adenovirus type 1 hepatitis and type 2 respiratory disease), P is parainfluenza and Pv is parvovirus. It is often called a 5-way vaccine because it covers canine distemper virus, adenovirus type 1, adenovirus type 2, parainfluenza virus and parvovirus.
The label says the first dose may be given at 6 weeks of age or older.
The label says to repeat the dose 2 to 4 weeks after the first, and that two doses are required for primary immunization. It also notes that because maternal antibodies interfere with active immunity, additional boosters will be required in most young animals. Ask your veterinarian how many to give.
Merck's label says annual revaccination has historically been recommended, but the need for that booster has not been established. Consult your veterinarian or Merck Animal Health about revaccination frequency.
Merck Animal Health states that Nobivac Canine 1-DAPPv protects against all known strains of canine parvovirus, including CPV-2c, and cites an independent study by Larson and Schultz.
No. For leptospirosis coverage, Merck makes Nobivac Canine 1-DAPPv+L4. For coronavirus, Merck makes Nobivac Canine 1-DAPPv+Cv.
Aseptically transfer the sterile diluent into the vaccine vial, mix gently until dissolved, then inject 1 mL subcutaneously or intramuscularly.
Refrigerate at 2°–8°C (35°–46°F). Do not freeze.
No. The label says not to vaccinate pregnant bitches.
The label says to vaccinate only healthy, non-parasitized dogs.
No. The label states it is thimerosal free. It contains gentamicin as a preservative.
No. The label says not to mix it with other products, except as specified on the label.
Vaccines ship UPS 2nd Day Air, packed in a styrofoam vaccine shipping cooler with 3 ice packs. The cooler and 3 ice packs are included at no extra charge. Extra ice packs beyond 3 can be added for a fee. Vaccine shipping is a flat rate by zone:
| Zone 1: $29.99 | KS, WI, OK, IL, LA, MI, AR, IN, MO, KY, IA, TN, MS, AL, GA, FL, SC, NC, VA, WV, PA, OH |
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| Zone 2: $39.99 | CT, MA, NJ, NY, RI, TX, VT, DE, MD |
| Zone 3: $69.99 | CO, NM, NE, SD, ND, MN, CA, UT, NV, WY, AZ, MT, ID, WA, OR, ME, NH |
| Other states (including AK and HI) | Call 800-979-2869 for a rate |
Overnight shipping is available for an additional charge: note it in the order comments at checkout or call 800-979-2869.
Melted ice packs are expected. The packaging protects the vaccine from large temperature swings during the 2-day trip; it is not designed to arrive at refrigerator temperature. Refrigerate the vaccine as soon as it arrives. Overnight shipping is available on request: note it at checkout or call 800-979-2869.
No. Vaccines and other perishable items cannot be returned or refunded.
From the Merck Animal Health label for Nobivac Canine 1-DAPPv (25 × 1 dose):
CANINE DISTEMPER-ADENOVIRUS TYPE 2-PARAINFLUENZA-PARVOVIRUS VACCINE, Modified Live Virus. FOR ANIMAL USE ONLY. IN THE ABSENCE OF A VETERINARIAN-CLIENT-PATIENT RELATIONSHIP, FEDERAL REGULATIONS PROHIBIT THE RELABELING, REPACKAGING, RESALE OR REDISTRIBUTION OF THE INDIVIDUAL CONTENTS OF THIS PACKAGE. THIMEROSAL FREE.
Indications: This product has been shown to be effective for vaccination of healthy dogs 6 weeks of age or older against canine distemper virus, canine adenovirus type 1 (hepatitis), canine adenovirus type 2 (respiratory disease), canine parainfluenza virus and canine parvovirus. Duration of Immunity has not been established. To review efficacy and safety data, go to productdata.aphis.usda.gov. Data indicate the development of corneal opacity is not associated with the use of this product.
Dosage and Administration: Transfer contents of the sterile diluent vial to the Nobivac Canine 1-DAPPv vial aseptically. Mix gently until dissolved. Inject one dose (1mL) subcutaneously or intramuscularly. The initial dose may be given at 6 weeks of age or older. Repeat dose 2 to 4 weeks later. Two doses are required for primary immunization. The presence of maternal antibodies is known to interfere with the development of active immunity in dogs and additional boosters will be required in most young animals. Historically, annual revaccination has been recommended for this product. The need for this booster has not been established. For more information on revaccination frequency, in general or in the face of maternal antibody, consult your veterinarian or the manufacturer.
Precautions: Store at 2°–8°C (35°–46°F). Do not freeze. Use new, non-chemically sterilized needles and syringes. Do not mix with other products, except as specified on the label. Inactivate unused contents before disposal. In case of human exposure, contact a physician.
Warnings: Contains gentamicin as a preservative. Vaccinate only healthy, non-parasitized dogs. Do not vaccinate pregnant bitches. The use of a biological product may produce anaphylaxis and/or other inflammatory immune-mediated hypersensitivity reactions. The age at which maternal antibody for canine parvovirus no longer interferes with the development of active immunity varies according to the bitch’s titer and quantity of colostral antibodies absorbed by the puppy.
Intervet Inc. d/b/a Merck Animal Health, Omaha, NE 68103 USA. VLN 165A / PCN 13D1.20.
This page summarizes the manufacturer's label and published product information. Always read and follow the label on the product you receive, and consult your veterinarian about the right vaccination program for your animals.
| Directions | Dosage and Administration: Transfer contents of the sterile diluent vial to the Nobivac Canine 1-DAPPv vial aseptically. Mix gently until dissolved. Inject one dose (1mL) subcutaneously or intramuscularly. The initial dose may be given at 6 weeks of age or older. Repeat dose 2 to 4 weeks later. Two doses are required for primary immunization. The presence of maternal antibodies is known to interfere with the development of active immunity in dogs and additional boosters will be required in most young animals. Historically, annual revaccination has been recommended for this product. The need for this booster has not been established. For more information on revaccination frequency, in general or in the face of maternal antibody, consult your veterinarian or the manufacturer. |
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